Scientific American posted an article this week. Behind the Buzz: How Ketamine Changes the Depressed Patient’s Brain. In this work, they take a look at new data supporting the effectiveness of Ketamine’s ability to cause remission through synaptogenesis.
Synaptogenesis, the formation of new connections in the brain, is believed to be one of the ways that Ketamine exerts its effects in humans. A new study, produced by multiple centers including Cornell and Stanford, utilized an animal model to demonstrate how this “Prefrontal cortical spine formation sustains the remission of specific depression-related behaviors after ketamine treatment…” Through their research, they were able to conclude that the preservation and enhancement of these synapses may be very useful in promoting sustained remission.